DiLorenzo has authored at least ten books, including:

DiLorenzo has devoted much effort to scholarly historical revisionism, focusing on what has been called "the Lincoln Cult" as a political and historical phenomenon. In the same vein, he has spoken out in favor of the secession of the Confederate States of America, defending the right of these states to secede in a view similar to that of abolitionist Lysander Spooner. He has also criticized the crediting of the New Deal for ending the Great Depression.

DiLorenzo lectures widely, and is a frequent speaker at Mises Institute events.